Methodological Challenges in Mendelian Randomization
نویسندگان
چکیده
منابع مشابه
Genetic epidemiology and Mendelian randomization for informing disease therapeutics: Conceptual and methodological challenges
The past decade has been proclaimed as a hugely successful era of gene discovery through the high yields of many genome-wide association studies (GWAS). However, much of the perceived benefit of such discoveries lies in the promise that the identification of genes that influence disease would directly translate into the identification of potential therapeutic targets, but this has yet to be rea...
متن کاملCommentary: Two-sample Mendelian randomization: opportunities and challenges
A et al. Body mass index and lung cancer risk: results from the ICARE study, a large, population-based case-control study. A et al. Stress decreases the ability to resist smoking and potentiates smoking intensity and reward. Anthropometric factors and ovarian cancer risk: a systematic review and nonlinear dose-response meta-analysis of prospective studies. Association of oral contraceptive use,...
متن کامل5. Mendelian randomization
Associations between modifiable exposures and disease seen in observational epidemiology are sometimes confounded and thus misleading, despite our best efforts to improve the design and analysis of studies. Mendelian randomization, the random assortment of genes from parents to offspring that occurs during gamete formation and conception provides one method for assessing the causal nature of so...
متن کاملMendelian randomization in family data
The phrase "mendelian randomization" has become associated with the use of genetic polymorphisms to uncover causal relationships between phenotypic variables. The statistical methods useful in mendelian randomization are known as instrumental variable techniques. We present an approach to instrumental variable estimation that is useful in family data and is robust to the use of weak instruments...
متن کاملPleiotropy-robust Mendelian randomization.
Background The potential of Mendelian randomization studies is rapidly expanding due to: (i) the growing power of genome-wide association study (GWAS) meta-analyses to detect genetic variants associated with several exposures; and (ii) the increasing availability of these genetic variants in large-scale surveys. However, without a proper biological understanding of the pleiotropic working of ge...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Epidemiology
سال: 2014
ISSN: 1044-3983
DOI: 10.1097/ede.0000000000000081